Bioengineering of the Skin: Skin Imaging & Analysis by Wilhelm, Klaus-Peter

By Wilhelm, Klaus-Peter

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Additional resources for Bioengineering of the Skin: Skin Imaging & Analysis

Sample text

Histology images were electronically acquired with a digital camera connected to a light-microscope (Fig. 11B). Again, images were registered with manually selected landmarks, and fused images were represented in one single coordinate system (Fig. 11C). This example illustrates that the fusion of tomographic images with histological sections offers a means to evaluate the noninvasive imaging technique regarding image content and the correct depiction of the skin structures. In Figure 12, an example of the fusion of OCT images with 3D histological image data is shown.

Tring FC, Lyndon BN. Surface microtopography of normal human skin. Arch Dermatol 1974; 109:223. 3. Wolf J. Die innere Struktur der zellen des stratum desquamans der menschlichen epidermis. Z Mikros Anat Forsch 1939; 46:170–202. 4. Goldschmidt H, Kligman AM. Exfoliative cytology of the human horny layer. Arch Dermatol 1967; 96:572–576. 5. Marks R. Clinical methods for measuring scaling and desquamation. Bioeng Skin 1987; 3:319–333. 6. Ryan RL, Hing SAO, Theiler RF. A replica technique for the evaluation of human skin by scanning electron microscopy.

For these reasons, imaging techniques support the dermatologist in making diagnoses of skin diseases and lesions. High-resolution microscopic imaging techniques are required because the interesting skin structures are very small. Optical Skin Surface Imaging The visual inspection by the dermatologist is the most common method to evaluate skin lesions and diseases. In conventional dermatoscopy, magnifying glasses are used to improve the visibility. However, the diagnostic output significantly depends on the individual experience of the physician.

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