Basic Research in Endocrine Dermatology: 3rd Teupitzer by Christos C. Zouboulis

By Christos C. Zouboulis

Dermatological learn has skilled a quick improvement within the final 20 years, even though, it has infrequently serious about the endocrine capabilities of the surface. just a couple of years in the past clinicians and researchers in dermatology began to discover the surface as a aim organ for many hormones. within the final years the surface has been well-known because the biggest endocrine, paracrine and autocrine organ of the physique. it could metabolize steroid hormones and to supply derivatives with possibly systemic job. issues of hormone metabolism can both set off direct results at the dermis or not directly disturb epidermis homeostasis. Endocrine dermatology is a brand new and intriguing region of epidermis learn. It comprises epidermis illnesses because of or linked to endocrine problems, dermis problems which might be taken care of with hormones or with compounds with hormone-like task, and dermis issues which take place as antagonistic occasions of hormone remedy or of remedy with compounds showing a hormone-like impact.

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Additional info for Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6)

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This model has received a great deal of experimental support [reviewed 7, 24] and is now well established. Androgen Receptors in Cultured Dermal Papilla Cells from Follicles with Differing Responses to Androgens in vivo Investigations into the mechanism of androgen action in cultured dermal papilla cells from human follicles with various responses to androgens in vivo have revealed the same paradoxes in vitro as seen in vivo. Both androgenstimulated beard [25] and androgen-inhibited balding scalp [26] dermal papilla cells contained higher levels of high affinity, low capacity androgen receptors than control non-balding scalp.

Pediatr Dermatol 1998; 15:253–258. 93 Radoja N, Komine M, Jho SH, Blumenberg M, Tomic-Canic M: Novel mechanism of steroid action in skin through glucocorticoid receptor monomers. Mol Cell Biol 2000;20: 4328–4339. 94 Randolph RK, Simon M: Metabolism of alltrans-retinoic acid by cultured human epidermal keratinocytes. J Lipid Res 1997;38: 1374–1383. 95 Zouboulis ChC, Orfanos CE: Retinoids; in Millikan LE (ed): Drug Therapy in Dermatology. New York, Marcel Dekker, 2000, pp 171–233. 96 Zouboulis ChC, Korge B, Akamatsu H, Xia L, Schiller S, Gollnick H, Orfanos CE: Effects of 13-cis-retinoic acid, all-trans-retinoic acid and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro.

Potential targets for androgens in the follicle include: the dermal papilla cells, since the dermal papilla size must be altered to change the hair size [22, 23]; the follicular keratinocytes, which divide and mature to form the hair and its various sheaths; the melanocytes, which alter the amount of pigment produced under different endocrine conditions; and the follicular endothelial cells as the larger the follicle the greater the blood supply will be required. In this hypothesis the actions of androgens would be interpreted by the dermal papilla cells and transmitted to the other target cells via paracrine factors.

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