Atlas of Graft-versus-Host Disease: Approaches to Diagnosis by Jonathan A. Cotliar

By Jonathan A. Cotliar

This atlas offers trainees and practising physicians a visible toolkit to assist realize and deal with this tough adequately. this article highlights the medical variability of GVHD, and fingers readers with the diagnostic clues to categorize sufferers in keeping with the present grading/staging instructions. in addition, this atlas bargains evidence-based diagnostic and remedy algorithms for physicians to take advantage of whereas at sufferers' bedsides.

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Extra resources for Atlas of Graft-versus-Host Disease: Approaches to Diagnosis and Treatment

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Fig. 12 Morbilliform lesions on the thighs Fig. 13 Morbilliform lesions diffusely located on the trunk Fig. 10 Morbilliform lesions on the dorsal forearms/hands Fig. 11 Morbilliform lesions on the chest and abdomen 3 Clinical Presentation of Acute Cutaneous Graft-Versus-Host Disease Erythroderma 25 Reticulated Patterns Erythrodermic aGVHD presents with confluent erythema- Acute GVHD may present in a reticulated, netlike pattern tous patches that mimic severe viral exanthema, drug reac- (Fig. 15).

GVHD represents a prime example in which vacuolar alteration of adnexae, principally of follicular units, may be encountered (Fig. 3) [23]. However, adnexal vacuolar change also may be found in systemic lupus erythematosus (SLE) and toxic erythema of chemotherapy (TEC). Theoretically, it may also be found in dermatomyositis, but this has not been consistently reported in the literature. Because of the uneven distribution of cutaneous adnexal structures, level sections should be obtained to search for follicular units and sweat gland epithelium when there is a high clinical index of suspicion for aGVHD.

Biol Blood Marrow Transplant. 2015;21:1167–87.  Female long-term survivors after allogeneic hematopoietic stem cell transplantation: evaluation and management. Semin Hematol. 2012;49:83–93. ; Centers for Disease Control and Prevention (CDC). Human papillomavirus vaccination: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2014;63:1–30. Erratum in: MMWR Recomm Rep. 2014;63:1182.  Miller Precise diagnosis of graft-versus-host disease (GVHD) remains elusive.

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