Applied Dermatotoxicology. Clinical Aspects by Howard Maibach, Golara Honari

By Howard Maibach, Golara Honari

Applied Dermatotoxicology: medical Aspects presents concise, systematic, and cutting-edge info at the toxicological results of drugs on epidermis, and up to date advances in dermal toxicity trying out.

This booklet particularly addresses the medical shows borne out of publicity to a number of chemical compounds. It starts with an summary of epidermis biology to supply toxicologists with a uncomplicated figuring out of its anatomy and body structure. subsequent it provides a number of dermatotoxicological results, besides on the poisonous brokers that reason them, with colour photos to demonstrate those results.

Applied Dermatotoxicology: medical Aspects is a vital reference for toxicologists in undefined, and for these doctors who come upon situations of dermal publicity to poisonous brokers.

  • A concise, but inclusive evaluation of results of chemical exposure
  • Includes historical past on easy epidermis biology
  • Provides very important scientific reference for toxicologists in non-clinical settings

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Contact Dermatitis. 2013; [Epub ahead of print]. 76. Lindberg M, Bingefors K, Meding B, et al. Hand eczema and health-related quality of life; a comparison of EQ-5D and the Dermatology Life Quality Index (DLQI) in relation to the Hand Eczema Extent Score (HEES). Contact Dermatitis. 2013;69:138À143. 77. Moberg C, Alderling M, Meding B. Hand eczema and quality of life: a population-based study. Br J Dermatol. 2009;161:397À403. 78. Bruze M, Fregert S, Gruvberger B. Chemical skin burns. In: Kanerva L, Elsner P, Wahlberg JE, Meibach HI, eds.

Philips L, Steinberg M, Maibach HI. A comparison of rabbit and human skin response to certain irritants. Toxicol Appl Pharmacol. 1972;21(3):369À382. 23. Frosch PJ, Kligman AM. The soap chamber test. A new method for assessing the irritancy of soaps. J Am Acad Dermatol. 1979;1(1):35À41. 24. Kooyman DJ, Snyder FM. Tests for the mildness of soaps. Arch Dermatol Syph. 1942;46:846À855. 25. Gabard B, Chatelain E, Bieli E, Haas S. Surfactant irritation: in vitro corneosurfametry and in vivo bioengineering.

Assessments of skin corrosivity and/or irritancy via RhE models are based on the premise that corrosive substances penetrate through the stratum corneum and are toxic to the underlying cells. 8 32 Applied Dermatotoxicology Cell viability is measured by enzymatic conversion of a vital dye into a blue formazan salt that is quantitatively measured after extraction from tissues. Two or three replicates are used for each test chemical and for the controls in each experiment. 9% NaCl. Then cell viability in RhE models is measured by enzymatic conversion of the vital dye MTT [3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, thiazolyl blue], into a blue formazan salt that is quantitatively measured after extraction from tissues.

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