Antidepressants: New Pharmacological Strategies by Luz Romero, Josep Ma Casanovas, Ildefons Hervás, Roser

By Luz Romero, Josep Ma Casanovas, Ildefons Hervás, Roser Cortés (auth.), Phil Skolnick (eds.)

In Antidepressants: present traits and destiny instructions, modern investigators distill the dramatic fresh advances in our figuring out of the mechanisms chargeable for antidepressant motion. The authoritative individuals supply suggestions to enhance present remedies grounded on biogenic amine-based suggestions. via departing from conventional techniques, the authors provide choices to cures that frequently paintings too slowly or in no way, and recommend how the numerous contemporary advances in molecular biology and genetics may most sensible be exploited within the layout of optimum new remedies.

Antidepressants: present traits and destiny instructions summarizes novel strategies of antidepressant treatment that try and take advantage of provocative new insights from the laboratory to enhance present, biogenic amine-based cures. Readers will locate the publication a great source in commencing the door to the improvement of more recent and more beneficial antidepressant therapies.

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However, although (-)pindolol blocked several 5-HTIA-mediated responses in the rat (104,117,118), it did not antagonize the 5-HTIA receptor-mediated hyperpolarization of pyramidal neurons in the CA3 field of dorsal hippocampus induced by the microiontophoretic application of 5-HT and 8-0H-DPAT (84). By contrast, the same dose of (-)pindolol prevented the reduction in firing of dorsal raphe 5-HT neurons induced by paroxetine and LSD (84,88). This differential activity at pre- and postsynaptic 5-HTIA receptors is analogous to that found for spiperone (119), and cannot be explained by the higher receptor reserve of 5-HTIA receptors in the raphe (120,121) (which would produce an opposite situation).

59. Levine, E. S. and Jacobs, B. L. (1992) Neurochemical afferentscontrolling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat. J. Neurasci. 12, 4037-4044. 60. Tao, R. and Auerbach, S. B. (1996) Differential effect of NMDA on extracellular serotonin in rat midbrain raphe and forebrain sites. J. Neurochem. 66, 1067-1075. 61. Artigas, E and Romero, L. (1996) Enhancement of SSRI effects by 5-HTIA antagonists. Regional selectivity and role of somatodendritic autoreceptors.

1. Pharmacol. Exp. Ther. 265, 16-23. O'Neill, M. , Fernandez, A. , and Palacios, J. M. (1996) GR 127935 blocks the locomotor and antidepressant-like effects of RU 24969 and the action of antidepressants in the mouse tail suspension test. Pharmacol. Biochem. Behav. 53,535-539. Borsini, F. (1994) Balance between cortical 5-HTIA and 5-HT2 receptor fuction: hypothesis for a faster antidepressant action. Pharmacol. Res. 30, 1-11. Charney, D. , Woods, S. Goodman, W. , and Heninger, G. R. (1987) Serotonin function in anxiety.

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